Endocrine Abstracts

Germline and somatic gene targeting of genes for steroid hormone receptor allows the characterization of their functions as well as their molecular modes of action. For the glucocorticoid receptor (GR) multiple modes of action have been identified. The receptor activates expression of genes, e.g. for gluconeogenic enzymes in hepatocytes, by binding as a dimer to glucocorticoid response elements (GRE) as well as by interaction with Stat5, functioning as a coactivator for DNA-bo...